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Chemical nameMethamphetamine (N-methylamphetamine)
Prescription brandDesoxyn (rarely prescribed)
Street namesMeth, crystal, ice, crank, glass, Tina
Drug classAmphetamine-type stimulant
US legal statusSchedule II; illicit manufacture and sale are federal crimes
How it is usedSmoked, snorted, injected, or swallowed
OnsetSeconds (smoked or injected) to 20 minutes (swallowed)
Duration8 to 24 hours
Half-lifeAbout 10 hours
Reversal agentNone
Methamphetamine is chemically close to amphetamine but enters the brain faster and releases more dopamine, which makes it more euphoric and more addictive. Desoxyn tablets are FDA-approved for ADHD but are rarely prescribed.[1][2]
Illicit methamphetamine is mostly produced in large labs abroad and is purer and cheaper than a decade ago. It is sold as clear crystals ("ice") or powder.[2]
Methamphetamine causes intense euphoria, alertness, energy, talkativeness, reduced appetite, faster breathing and heart rate, higher blood pressure, and raised body temperature.[2]
Effects start within seconds when smoked or injected and last 8 to 24 hours, much longer than cocaine. Binges lasting days without sleep are common.
Heart and brain: heart attack, dangerous heart rhythms, heart failure, stroke, and very high body temperature.[2]
Mental health: anxiety, paranoia, hallucinations, aggression, and psychosis that can persist after use stops.[2]
Physical: severe dental decay ("meth mouth"), skin sores from picking, weight loss, and HIV and hepatitis risk from injection and sexual behavior.
Warning: Fentanyl is increasingly found in methamphetamine. People who do not use opioids have no tolerance, so even small amounts of fentanyl can be fatal. Carry naloxone and use fentanyl test strips.
Choose what it would be combined with:
Fentanyl and other opioidsOther stimulants (cocaine, MDMA, ADHD medicines)MAOIsAlcoholSSRIs, MDMA, tramadol
| Combined with | What happens | Risk level |
|---|---|---|
| Fentanyl and other opioids | Overdose; opioid effects hit when meth wears off | Leading cause of stimulant-involved deaths |
| Other stimulants (cocaine, MDMA, ADHD medicines) | Extreme heart strain, overheating | Very high risk |
| MAOIs | Dangerous rise in blood pressure | Potentially fatal |
| Alcohol | Masks drunkenness, leading to alcohol poisoning; heart strain | High risk |
| SSRIs, MDMA, tramadol | Serotonin syndrome | High risk |
This is not a full list. Unregulated drugs often contain other substances, which makes any combination less predictable.
Methamphetamine overdose can cause chest pain, very fast or irregular heartbeat, very high body temperature, severe agitation or paranoia, seizures, stroke, and collapse. Many overdose deaths involving methamphetamine also involve fentanyl.[2]
Methamphetamine is highly addictive. Withdrawal is not usually physically dangerous but is intensely unpleasant and a common trigger for relapse.[2]
There is no FDA-approved medicine for methamphetamine use disorder. Contingency management, which gives rewards for drug-free tests, is the most effective treatment, and naltrexone plus bupropion has shown benefit in a clinical trial.[2]
Methamphetamine is Schedule II: it has a recognized medical use as Desoxyn, but making, selling, or possessing it without a prescription is a federal crime. Pseudoephedrine, a precursor, is sold behind the pharmacy counter with ID and monthly limits under the Combat Methamphetamine Epidemic Act.[3]
Contingency management programs are offered through some treatment centers and, since 2023, through several state Medicaid programs.
| Country | Status |
|---|---|
| United Kingdom | Class A |
| Canada | Schedule I |
| Australia | Schedule 9 prohibited substance |
| International | Schedule II of the 1971 Convention on Psychotropic Substances |
Laws change and differ in detail. Check current rules before carrying any controlled medicine across a border.
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