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Adderall (Amphetamine) at a glance: schedule, half-life, and class

Generic nameMixed amphetamine salts (dextroamphetamine and amphetamine)

Brand namesAdderall, Adderall XR, Mydayis; also Evekeo, Adzenys XR-ODT

Drug classAmphetamine-type central nervous system stimulant

US legal statusSchedule II, prescription only

Approved usesADHD (age 6 and up for most forms); narcolepsy

FormsTablets, extended-release capsules, orally disintegrating tablets

Onset30 to 60 minutes

Duration4 to 6 hours (IR); 10 to 12 hours (XR)

Half-lifeAbout 10 to 13 hours

How it worksReleases dopamine and norepinephrine

Adderall uses: what amphetamine is prescribed for

Adderall is approved for attention-deficit/hyperactivity disorder (ADHD) and narcolepsy. Adderall XR and Mydayis are approved for ADHD.[1]

Amphetamines release dopamine and norepinephrine in the brain, which improves attention, focus, and impulse control in people with ADHD. Stimulants are the most effective medicines for ADHD, helping about 70 to 80% of people.

Adderall dosage: how amphetamine is usually prescribed

The figures below come from the FDA-approved label and describe how prescribers typically use amphetamine. They are not personal dosing advice. A prescriber sets the dose for each person and adjusts it over time.[1]

Doses are taken in the morning, with the second immediate-release dose 4 to 6 hours later, to limit insomnia. Clinicians check blood pressure, heart rate, and, in children, growth.

Adderall (amphetamine) side effects and risks

FDA boxed warning

• Adderall has a high potential for abuse and misuse, which can lead to a substance use disorder, including addiction. Misuse and abuse of CNS stimulants can result in overdose and death, and this risk is increased with higher doses or unapproved methods of administration, such as snorting or injection.[2]
• Prescribers should assess each patient's risk before prescribing, monitor for signs of misuse throughout treatment, and counsel patients not to share their medicine.[2]

Common side effects include decreased appetite, trouble sleeping, dry mouth, stomach pain, headache, weight loss, nervousness, and fast heart rate.[1]

Serious risks include sudden death in people with heart defects or serious heart problems, stroke and heart attack in adults, high blood pressure, new psychosis or mania, slowed growth in children, poor circulation in fingers and toes (Raynaud's), and serotonin syndrome.[1]

Adderall interactions: what not to mix with amphetamine

Choose what it would be combined with:

MAOIs (phenelzine, selegiline, linezolid)Other stimulants, decongestants (pseudoephedrine)SSRIs, SNRIs, tramadol, triptansAlcoholAntacids and urine alkalinizers (sodium bicarbonate)Vitamin C and acidic juicesFluoxetine, paroxetine, bupropion (CYP2D6 inhibitors)

This is not a full list. A pharmacist can check a complete medication list, including supplements and over-the-counter products.[1]

Adderall overdose: signs of amphetamine overdose and what to do

Stimulant overdose causes restlessness, agitation, tremor, fast breathing, confusion, hallucinations, panic, very high body temperature, high or low blood pressure, chest pain, irregular heartbeat, seizures, and collapse.[1]

If someone may be overdosing

• Call 911 for chest pain, a seizure, trouble breathing, signs of a stroke (face drooping, weakness on one side, slurred speech), a very high body temperature, or if the person collapses.
• Move them somewhere cool and calm, loosen tight clothing, and cool the skin with water. Do not try to hold them down.
• If they become unresponsive or their breathing slows, give naloxone. Street stimulants are often contaminated with fentanyl.
• For advice when the person is awake and stable, call Poison Help at 1-800-222-1222.

What happens when you stop Adderall?

Stopping Adderall after regular prescribed use does not cause dangerous physical withdrawal. ADHD symptoms return, and some people feel tired or low for a few days. After heavy misuse, a "crash" with exhaustion, increased sleep and appetite, and depression is common.[1]

1. Days 1 to 3CrashFatigue, long sleep, increased appetite, low mood, irritability.
2. Weeks 1 to 2Low mood and cravingsLow energy, poor concentration, and cravings after heavy use.
3. Weeks to monthsRecoveryMood and energy normalize; depression should be watched for.

There is no need to taper prescribed stimulants for safety, but anyone who feels severe depression or suicidal thoughts after stopping should contact a clinician or call or text 988.

How to get prescribed Adderall (amphetamine) legally in the US

In the United States, amphetamine is a Schedule II controlled substance. The only legal way to get it is with a prescription from a clinician registered with the Drug Enforcement Administration (DEA), filled by a licensed pharmacy. Depending on state law, that can be a physician, nurse practitioner, or physician assistant.[3]

• Refills: Schedule II prescriptions cannot be refilled. A prescriber can write several prescriptions at once, with dates when each may be filled, for up to a 90-day supply in total.[4]
• Telehealth: federal flexibilities let DEA-registered clinicians prescribe Schedule II to V medicines after a telemedicine visit, without a prior in-person exam, through December 31, 2026. A permanent DEA rule was under final review in late 2026. State rules can be stricter.[5]
• Monitoring: prescribers and pharmacists in most states check a prescription drug monitoring program, a database of controlled-substance prescriptions, before prescribing or dispensing.
• Pharmacies: a legitimate pharmacy always requires a valid prescription, has a licensed pharmacist available, and is licensed in the state it ships to. The FDA's BeSafeRx tool and the NABP's safe pharmacy list help confirm a pharmacy is real.[6][7]
• Cost: generic Adderall and Adderall XR are widely covered; some plans limit quantities or require prior authorization for adults.
• Shortages: prescription stimulants were in short supply from 2022, and some strengths remained hard to find into 2025. If a pharmacy is out, ask about another strength, form, or nearby pharmacy, or ask the prescriber about alternatives.

Warning: Pills sold as Adderall outside a pharmacy are often counterfeit. The DEA reports that fake pills frequently contain fentanyl or methamphetamine, and they cannot be told apart by appearance.[8]

Traveling: keep the medicine in its original pharmacy container and carry a copy of the prescription. Check the rules of the destination country before travel, because many countries restrict controlled medicines or require a permit.

Can you order Adderall (adderall) online legally?

Yes, but only with a valid prescription and only from a pharmacy licensed in your state. Many licensed pharmacies, including mail-order pharmacies run by insurers, fill adderall prescriptions online and ship them. Buying adderall from a website that does not require a prescription is illegal, and the product is often fake.[6][8]

1. See a licensed clinicianA clinician evaluates you in person or by telemedicine and decides whether adderall is appropriate.
2. The prescription goes to a pharmacyPrescriptions for controlled medicines are usually sent electronically, straight from the prescriber to the pharmacy you choose.
3. The pharmacy checks and fills itA pharmacist verifies the prescription and your identity, then dispenses the medicine in person or by mail.

Signs that an online seller is illegal:

• It sells adderall with no prescription, or after only a short online questionnaire.
• It takes orders through social media, messaging apps, or email.
• It asks for payment in cryptocurrency, gift cards, or money transfers.
• It has no US street address, no state pharmacy license, and no pharmacist to speak to.
• Its prices are far below those of ordinary pharmacies, or it ships from another country.

The FDA's BeSafeRx tool links to each state's license lookup, and the National Association of Boards of Pharmacy lists verified online pharmacies.[6][7]

Adderall price: how much does Adderall (amphetamine) cost without insurance?

Generic Adderall and Adderall XR are widely covered; some plans limit quantities or require prior authorization for adults.

What you pay depends on the strength, the number of doses, your insurance plan, and the pharmacy. Cash prices for the same prescription can differ several times over between pharmacies in the same town, so check current prices before you fill it.

Ways to pay less, legally:

• Ask the prescriber whether a generic amphetamine is available. FDA-approved generics work the same way as the brand and usually cost much less.
• Compare cash prices between pharmacies before you fill the prescription.
• Use a free prescription discount card, such as GoodRx or SingleCare, when you pay cash. These cards cannot be combined with insurance on the same fill.
• For brand-name medicines, check the manufacturer's savings program or patient assistance program.
• Check your insurer's mail-order pharmacy, which may charge a lower copay.